He was hell-bent on going in spite of the heavy rain.
Try to sleep in spite of the noise.
despite,in spite of,notwithstanding
这些前置词或前置短语都含有“虽然，尽管”之意。 despite书面用词，指不受某事或某种原因的阻碍，语气轻于in spite of。 in spite of在这些词中语气最强，可与despite换用，口语或书面语中均可使用。 notwithstanding语气最弱，仅表示一种障碍的存在。
He went fishing in spite of rain.
In spite of this, I slept heavily.
I went shopping in spite of the rain.
They persevered in spite of all kinds of difficulties.
Some would spill in spite of the gang's threats.
They are both very cheerful in spite of their colds.
In spite of his vices, he was loved by all.
In spite of the recession, profits have galloped ahead.
In spite of my outward calm I was very shaken.
The balloonist cheated death in spite of the storm.